S Bloodwater is a strategy management defense game inspired by the S Foundation's S-354 ("The Red Pool").

In this game, you take the role of a newly appointed Site Director at the Red Pool Containment Zone, also known as the Area-354 Containment Site. Your mission as the new Site Director is threefold:

1) Harvest Resources
2) Attack and Defend
3) Research and Progress

Be warned; this is an anomalously strategic game.

★ Which research should you do first?
★ How many D-Class should you deploy?
★ What type of military unit should you use against that beast?
★ Should you retreat now and save your team or continue the assault?
★ Should you focus on your military and conventional weapons or research genetics instead and use the Red Pool's monsters against it?
★ Do you have what it takes to defend your base until the Red Pool awakens?

In this universe, S-354 has been elevated to Thaumiel for the discovery of S-354-B, which is a valuable organic material that drops from entities that S-354 manifests, referred to as S-354-A.

For this reason, the S Foundation has launched operations in order to harvest more S-354-B which in turn had only made S-354 angry. Consequently and unsurprisingly, the more they harvest S-354-B and the more they slaughter S-354-A entities, the larger and stronger the swarms become. But you have no choice, similar to the Y-909 compound, S-354-B is just too valuable so these harvesting operations must continue as much as possible.